One of the most commonly prescribed anti-inflammatory drugs is Prednisone. In some cases, this tool is indispensable, and in some - even able to save a person’s life. They can treat both children and adults. Prednisolone is available in various dosage forms and dosages.
And every patient should know not only about the merits of the drug and its indications, but also its minuses and side effects. Prednisone is a synthetic analogue of the hormone of the adrenal glands - hydrocortisone and has a similar effect to it. The main functions of the drug: anti-inflammatory, immunosuppressive, anti-allergic, anti-shock.
People shopping for Prednisone often choose online pharmacies because they offer a more comfortable and beneficial option. You can order this medication while staying home, and it will be delivered right at your doorstep. The mechanism of action of the drug in many ways still not exactly installed. We can only say that buy Prednisone affects almost all stages of the inflammatory process, inhibits the synthesis of inflammatory mediators - cytokines and histamine, and prevents the migration of immune system cells. Any medication that contains Prednisolone acts on specific glucocorticosteroid receptors located in various tissues. Especially many of these receptors in the liver. Prednisolone reduces cell wall permeability and has a moderate vasoconstrictor effect. It also affects the metabolism - lipids, proteins, carbohydrates, sodium ions and calcium, retains water in the body. During the period of therapy, periodic monitoring of electrolyte level, blood pressure, glucose level, and the state of the organs of vision is necessary. X-ray monitoring of bones and joints is recommended. The use of pregnancy and lactation Many probably wondered whether it is possible to use the tool during pregnancy. This is not highly recommended. The fact is that, in its composition Prednisolone enters the body of the fetus, and as shown by studies on animals, can produce a teratogenic effect, that is, a negative impact on the development of the fetus. This effect is particularly pronounced at the very beginning of pregnancy, in its first trimester.
Date/Time: 03-Jul-19 12:16 PM
Quickly relieves symptoms, Prednisone has a great effect, without a prescription, really helps very well.
The effect of the drug on protein metabolism is that it reduces the amount of albumin in the plasma and increases their amount in the composition of the liver, reduces protein synthesis in muscle tissue. Impact on lipid metabolism is to enhance the synthesis of higher fatty acids and triglycerides, the redistribution of adipose tissue. The effect on carbohydrate metabolism is expressed in enhancing the absorption of glucose from the gastrointestinal tract, stimulating the flow of glucose from the liver into the blood. For these reasons, Prednisone contributes to hyperglycemia. Prednisolone retains sodium in the body, but stimulates the excretion of potassium, reduces bone mineralization and slows down the absorption of calcium from the gastrointestinal tract. The mechanism buy Prednisone online which the anti-inflammatory effect of the drug is realized is versatile. First of all, Prednisolone prevents the release of inflammatory mediators from mast cells, reduces capillary permeability, stabilizes cell membranes. In addition, Prednisone violates the synthesis of prostaglandins from arachidonic acid, cytokines (interleukins, a special protein - tumor necrosis factor). Prednisolone also has an immunosuppressive effect. It interferes with the interaction of various types of lymphocytes and their migration, reduces the intensity of the formation of antibodies, blocks the release of interferons. The antiallergic effect is due to a decrease in the secretion of inflammatory mediators, inhibition of the release of histamine from mast cells, and suppression of the activity of lymphocytes contained in the blood. Prednisolone reduces the sensitivity of receptors in various tissues to inflammatory mediators.
Prednisone often is prescribed during replacement therapy, in case of insufficient functional activity of the adrenal glands. However, in this case, it should be borne in mind that the mineralocorticoid activity of the drug is lower than that of hydrocortisone. Therefore, patients with insufficient adrenal function should be treated not only with Prednisolone, but also with mineralocorticoids. It also acts on the adrenal glands, inhibiting the production of their natural hormones. Therefore, with prolonged administration of buy cheap Prednisone the drug, adrenal dysfunction may be observed, which becomes noticeable after the end of treatment. Over time, this phenomenon usually passes. Tablets have the widest range of indications. In this case, it is important that skin diseases are not caused by infectious causes. Otherwise, the drug can lead to inhibition of immunity and its use will only encourage the development of the disease. That is why Prednisolone is not prescribed as an ointment for skin infections. The pharmaceutical industry produces Prednisone in various forms, each of which is intended for use in certain diseases and situations in which the patient finds himself. For example, tablets are best suited for the treatment of chronic inflammatory or allergic processes. However, here we must take into account the seriousness of the situation in which it is assigned.
If we are talking about stopping a severe allergic reaction, such as anaphylactic shock, then all possible prohibitions fade into the background. After all, it is a state that threatens life. Such evidence is called life. With vital indications, the only case where it is impossible to take a remedy is its individual intolerance. However, if we are talking about long-term therapy with Prednisolone, then here the situation when it can not be taken, are much more common. A weighty list of contraindications should be attributed to the disadvantages of the drug. As with indications, contraindications for different dosage forms may not be the same. The most extensive list of contraindications for tablets and solution. In general, the list of prohibitions is based on the types of effects that buy Prednisone without prescription produces on the body. For example, despite the fact that the agent is prescribed for certain cardiovascular diseases, it cannot be used for acute or subacute myocardial infarction. This is due to the fact that Prednisone blocks the formation of scar tissue on the heart. As a result, the area of necrosis in the heart may expand, and a heart failure may even occur. It should also be borne in mind that Prednisolone affects the production of glucose in the body. This means that it can contribute to an increase in body weight. Therefore, people with obesity should also not be used. In addition, it stimulates the production of pepsin and hydrochloric acid in the stomach, which predetermines its prohibition in case of peptic ulcer of this organ and duodenum. The disadvantage of the remedy (unlike other glucocorticosteroids) is that it is prohibited in violation of the arachidonic acid metabolism.
The therapeutic effect of the drug in obstructive processes in the airways is due to the effect on inflammatory processes, a decrease in the swelling of the mucous membranes and viscosity of mucus, an increase in the sensitivity of adrenoreceptors to sympathomimetics. In case of shock conditions, buy generic Prednisone increases blood pressure, reduces the permeability of vascular walls, has a membrane-protective effect, activates liver enzymes involved in metabolic processes. Also, the drug prevents the development of lymphoid and connective tissue. Prednisolone in the form of an ointment, in addition to anti-inflammatory, anti-allergic and anti-edema effects, also prevents the occurrence of itching. In its anti-inflammatory activity, Prednisolone is 4 times as high as hydrocortisone. However, Prednisone is not the strongest of the synthetic glucocorticosteroid hormones. In addition, it is 40% inferior to the natural adrenal hormone hydrocortisone in mineralocorticoid activity. The drug is able to inhibit the synthesis of corticotropin and endogenous glucocorticosteroids. When administered as a pill, the maximum plasma concentration is observed after 90 minutes, with intravenous administration - after 30 minutes. The active substance may be in the composition of the blood for a long time. The half-life is 200 minutes.
The use of the drug is extremely wide, and it is often necessary to use it in different dosage forms in different situations. This means that the patient is not always free to switch from pills to injections, and then, for example, to ointment. In general, the drug is most often used to relieve symptoms of inflammatory processes of moderate and high severity. These processes can be localized in the following parts of the body: musculoskeletal system, blood system, lungs, gastrointestinal tract, muscles, nervous system, skin, eyes. Also one of the main directions of buy brand Prednisone is to combat systemic allergic reactions, such as angioedema and anaphylactic shock, especially when they take a scale that threatens the functioning of the body. And the use of the drug in the form of an injection or pill in a similar situation can save a person's life. Another important area of use of the drug in which it is able to prevent the development of life-threatening processes is anti-shock therapy. Often, Prednisolone is prescribed for various shock conditions. This may be cardiogenic, burn, surgical, toxic, traumatic shock. Here Prednisone is most often used in case of ineffectiveness of vasoconstrictor agents and other symptomatic therapy. The drug is used in such a dangerous complication as brain swelling. This condition may occur as a result of injuries, infectious and inflammatory processes, and surgical intervention.
Indications for taking the drug also include eye diseases of an allergic and inflammatory nature - allergic conjunctivitis, sympathetic ophthalmia, uveitis, optic neuritis. And the use of medication for such diseases helps not only to relieve swelling and inflammation, but also often to avoid vision loss. Prednisolone is also prescribed for some types of oncological diseases, for example, for lung cancer, multiple myeloma. In addition, the drug is useful in the treatment of complications of cancer, for example, hypercalcemia. Prednisolone is also prescribed to buy Prednisone at online pharmacy reduce nausea and vomiting during treatment with cytotoxic agents. The ability of the drug to suppress the immune response is not only useful in the treatment of autoimmune diseases. Due to this feature, Prednisone is prescribed for the prevention of rejection of transplanted donor organs. It is necessary to note one important circumstance - because many people forget about this minus of the drug. Despite the fact that the main purpose of Prednisolone - the fight against inflammation, this does not mean that the tool will be effective in infectious diseases. Moreover, for diseases caused by bacteria or viruses, taking the drug is not recommended. Here it should be remembered that one of the properties of the drug is immunosuppression. And the use of medication can lead to the fact that the bacteria and viruses in the body exposed to Prednisolone, feel at ease. Therefore, if one cannot do without a drug in such a case, then it should be used as part of a complex therapy, which should also include measures aimed at eliminating the causative agents of the disease, for example, taking antibiotics.
Not recommended for use in acute or chronic infections of viral or bacterial nature, parasitic diseases. This is not surprising, because Prednisolone inhibits many immune mechanisms, making the disease takes a heavy or protracted nature. Particular caution should be observed with tuberculosis, various types of herpes, mycoses, amebiasis. In some cases, the use of tools in infectious diseases is permissible, however get prednisone, subject to the simultaneous implementation of adequate etiotropic therapy. Do not use the drug in patients undergoing vaccination, because the weakening of the immunity caused by the drug may make it difficult to form resistance to the disease against which the vaccine is directed. The ban period lasts for 2 months before vaccination and 2 weeks after this procedure. It is not recommended to use the drug in immunodeficient states. Also not recommended for long-term use in children, since an excess amount of Prednisone can adversely affect the formation of a young body. In pediatric practice, the tool can be used only under strict medical supervision, in the minimum effective dose and minimally short courses. Even local forms should be used with care in children, since they are more likely to enter the systemic circulation than in adults, due to the larger ratio of body area to its mass in children. The number of contraindications for ointment and eye drops is less than that of tablets and solution. And this is not surprising, because the medicine in the form of ointment and drops acts only locally, without penetrating into the systemic circulation. Therefore, the disadvantages with this use of the drug is much less. Due to the fact that the drug is not allowed in a large number of cases, before starting therapy, the patient should be examined for the presence of pathologies in which its reception can lead to negative consequences. The study should include examination of the cardiovascular system, stomach, urinary organs.
During other periods of pregnancy, reception is also undesirable. In particular, adrenal atrophy may develop in the third trimester. However, in cases where the medication is not enough, it is still prescribed to women awaiting addition to the family. But it should be remembered that during pregnancy, treatment is necessarily buy Prednisone online carried out under the supervision of a physician. After birth, a child whose mother has taken Prednisolone may experience adrenal suppression. Although a very small dose of the drug penetrates into breast milk (approximately 1% of the blood concentration), however, this is enough to have a negative effect on the body of the newborn. Therefore, in such cases, mothers are encouraged to stop breastfeeding. Side Effects The drug affects various biochemical and physiological processes in the body. And this means that it affects various body systems and groups of organs. When taking the medication often occurs hypokalemia syndrome, expressed in arrhythmias, severe fatigue and weakness, muscle pain. In children, ossification can slow down and growth slows down. Therefore, the attending physician should monitor the growth dynamics of the child in case of long-term therapy. In tablets and injection, the likelihood of systemic side effects is much higher than that of the local forms - drops and ointments. In addition, with injections, such phenomena as pain, the development of infections and numbness at the injection site are possible.
With intramuscular injection, atrophy of subcutaneous tissue is possible. When applying the ointment may cause steroid acne, burning, itching, irritation and dry skin. The most dangerous side effect that occurs with long-term use of eye drops is an increase in intraocular pressure. For this reason, drops containing Prednisone are not recommended for more than 10 days. The development of posterior capsule cataract is also possible. Of course, the number of cases when, after taking a patient would appear severe reactions, is a small percentage. Nevertheless, such a situation is possible, and we should be prepared for it. Also, to ensure the minimum number of negative manifestations purchase Prednisone during therapy, the patient should follow a diet. The diet should include a minimum of fat, salt and carbohydrates, a large amount of protein and vitamins. After the end of long-term therapy during the year, the development of acute adrenal insufficiency is possible. In old age, the number of adverse reactions increases. Overdose when taking pills or parenteral administration is manifested in increased side effects. Symptomatic therapy and gradual withdrawal of the drug are recommended. In case of overdose of ointment and eye drops, hypersensitivity reactions are possible. In the case of an ointment, it is possible to completely stop using the product. Means in the form of tablets or solution for injection may cause side effects in the form of dizziness, so patients are not recommended during the course of therapy to drive vehicles or perform work requiring concentration of attention.
What time of day is it better to take pills? If the dose is small, then all pills are best taken in one morning intake. If the dose is significant, then it can be divided into 2-4 doses, with most of the daily dose taken in the morning. This circumstance is due to the fact that in humans, the release of the main dose of the natural adrenal hormones occurs just in the morning. Thus, such a regimen does not allow the body to stray too much from the natural rhythm. Tablets are best taken with or immediately after a meal. And a few more words should be said about how to buy Prednisone the discontinuation of the medication should take place after its long use. The disadvantage of the drug is its inherent effect of the syndrome. In no case should not abruptly throw admission after a long course of treatment, since in this case, the possible withdrawal of the syndrome and deterioration of health, as well as exacerbation of symptoms of the disease, about which therapy was prescribed. It is necessary to red more at accutane online reduce the dose gradually, until the body becomes accustomed to the low doses of hormones that come with the medication, and will not switch to its own. The method of reducing the dosage in this case is the following - a decrease in the amount of the medication taken occurs every 3-5 days, and from the dosage it is first subtracted by 5 mg, then by 2.5 mg. First of all, they cancel the latest receptions. The longer the treatment period was, the slower the dosage reduction procedure should be.
Prednisone, prednisolone, and dexamethasone are medicines that help reduce inflammation and swelling in the airways. You may need to take these medicines for a few days only when you have problems with asthma or trouble with breathing, coughing or wheezing. You also might hear these medicines called corticosteroids. These corticosteroids are not the same type of steroid that athletes use to make them better at their sports. These medicines do not cause the same types of side effects as the steroids that athletes use. Using corticosteroids for a short time does not have an effect on the body’s immune system.